Short- and Long-Term Biological Variation in Cardiac Troponin I with a High-Sensitivity Assay: Implications for Clinical Practice
نویسندگان
چکیده
BACKGROUND: The improved detection limit and precision in new-generation commercial assays for cardiac troponin I (cTnI) have lowered the 99th-percentile cutoff value, yielding higher frequencies of positive test results. Because serial testing is important in interpreting low concentrations, we evaluated the biological variation of cTnI in both the short (hours) and long (weeks) terms and determined reference change values (RCVs) and the index of individuality (II) for cTnI.
منابع مشابه
Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay.
BACKGROUND High-sensitivity cardiac troponin assays will augment the frequency of increased results, making important the determination of reference change values to distinguish acute from chronic increases. We assessed short- and long-term biological variability of cardiac troponin T (cTnT) in healthy subjects with a novel high-sensitivity (hs) assay. METHODS We collected blood from 20 healt...
متن کاملShort- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice.
BACKGROUND The improved detection limit and precision in new-generation commercial assays for cardiac troponin I (cTnI) have lowered the 99th-percentile cutoff value, yielding higher frequencies of positive test results. Because serial testing is important in interpreting low concentrations, we evaluated the biological variation of cTnI in both the short (hours) and long (weeks) terms and deter...
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